14 Comments
User's avatar
Mike Collins's avatar

I appreciate your nuanced view on this Ethan. I have been in a cycle of loss and gain for 30 years. Finally decided to try a GLP-1 after a great convert with Spencer. Now a year later and 130lbs down(90 GLP-1) the changes are stunning. Doing krav maga, trail running, indoor rock climbing…buying clothes off the rack in a non fat guy store. It’s repaired my relationship with food. I think these meds are a miracle.

Expand full comment
Ethan Suplee's avatar

Brother, I’m SO happy for you! And bouldering sounds incredible and terrifying!

Expand full comment
Mike Collins's avatar

Thank you man!

Expand full comment
My Almost 600 Lb Life's avatar

GLP-1’s are what finally saved my life. After I was diagnosed with diabetes, my doctor put me on one. It completely changed everything - EVERYTHING - about how I approached food. Two years and 170 pounds later, I’m almost at my goal weight. I’ve been on a diet since I was 12. All I ever did was get fatter. These meds are truly transformative.

Expand full comment
Ethan Suplee's avatar

I really love this kind of success story!! I’m so happy for you!

Expand full comment
Crystal Keyser's avatar

Ethan… I am only an onlooker, who began enjoying your acting in “My Name Is Earl” many years ago, and caught a random post of yours and was immediately impressed: by your achievements and your ability to articulate the saga therein…😌💕

I am simply glad to have seen your post and happy to read your musings… I find them entirely relatable and honest💕😌

Keep it up; you’re making a difference!!!

Expand full comment
Ethan Suplee's avatar

Thanks Crystal!

Expand full comment
René García's avatar

Really enjoyed this read. You do a great job empathizing with those of us in bigger bodies and the way these solutions can be such a source of support and freedom. I’m anxious to see more research come out on the long term effects as well as the mental health implications. 👊🏽

Expand full comment
Ulysses Santillan's avatar

Thanks for the read. Always insightful. Enjoy the day

Expand full comment
Adam Russell's avatar

Great article. I have done a lot of research on Glp-1’s. Not because I want to try them, but out of genuine interest. I have been on my own health journey since Christmas of 2023. I have been on short health kicks in the past, but this one is different. It is a lifestyle change coupled with understanding of what I was doing to myself. Now I may be a little different in that I am legitimately enjoying the journey. I don’t focus on the scale, I enjoy my workouts and I look for progress on lots of front to keep me moving. But I know others don’t or can’t have the same journey. So I don’t begrudge anyone for trying or using GLP-1’s. The negative outcomes of the extra weight are far greater than the risks associated with the use. I just hope that those who use them seek professional guidance on the necessary lifestyle changes that are needed to be healthy after the peptides are removed. But to your point..the future for weight loss and potential for healthy living is very different than it was 5 yrs ago.

Expand full comment
Randolph Carter's avatar

Man, I remember taking ephedra (I can't remember the brand name but they called it the ECA stack) in middle school around 1996 because I wanted to lose weight so I could play football with people my age instead of the high schoolers. What a wild unintentional first drug experience - I was up til 3 in the morning with my heart pounding, but I did indeed start shedding pounds. Until it was banned 😂

Expand full comment
Randolph Carter's avatar

Hydroxycut! I think that's what it was called

Expand full comment
Daniel Smith's avatar

Just found your substack via an Instagram post of all things. I've never read such an accurate reflection of my own weight loss journey, which has itself exposed a far more important self awareness and self acceptance journey. Perhaps there are those whose weight is isolated from their sense of self, but not based on my sample of one.

Expand full comment
Chris Harrison's avatar

Thank you, Ethan, for such a great read! I have just published a piece about my experience. Brothers, please read it; I really hope it helps.

https://open.substack.com/pub/progressmakesyoufeelalive/p/man-on-mounjaro?r=52plzl&utm_medium=ios

Expand full comment